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One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function

Overview of attention for article published in Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, August 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#11 of 1,664)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
68 news outlets
blogs
7 blogs
policy
1 policy source
twitter
63 tweeters
facebook
7 Facebook pages
googleplus
1 Google+ user
reddit
2 Redditors

Readers on

mendeley
23 Mendeley
Title
One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function
Published in
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, August 2016
DOI 10.1161/jaha.116.003858
Pubmed ID
Authors

Xiaoyin Wang, Ronak Derakhshandeh, Jiangtao Liu, Shilpa Narayan, Pooneh Nabavizadeh, Stephenie Le, Olivia M. Danforth, Kranthi Pinnamaneni, Hilda J. Rodriguez, Emmy Luu, Richard E. Sievers, Suzaynn F. Schick, Stanton A. Glantz, Matthew L. Springer, Wang, Xiaoyin, Derakhshandeh, Ronak, Liu, Jiangtao, Narayan, Shilpa, Nabavizadeh, Pooneh, Le, Stephenie, Danforth, Olivia M, Pinnamaneni, Kranthi, Rodriguez, Hilda J, Luu, Emmy, Sievers, Richard E, Schick, Suzaynn F, Glantz, Stanton A, Springer, Matthew L

Abstract

Despite public awareness that tobacco secondhand smoke (SHS) is harmful, many people still assume that marijuana SHS is benign. Debates about whether smoke-free laws should include marijuana are becoming increasingly widespread as marijuana is legalized and the cannabis industry grows. Lack of evidence for marijuana SHS causing acute cardiovascular harm is frequently mistaken for evidence that it is harmless, despite chemical and physical similarity between marijuana and tobacco smoke. We investigated whether brief exposure to marijuana SHS causes acute vascular endothelial dysfunction. We measured endothelial function as femoral artery flow-mediated dilation (FMD) in rats before and after exposure to marijuana SHS at levels similar to real-world tobacco SHS conditions. One minute of exposure to marijuana SHS impaired FMD to a comparable extent as impairment from equal concentrations of tobacco SHS, but recovery was considerably slower for marijuana. Exposure to marijuana SHS directly caused cannabinoid-independent vasodilation that subsided within 25 minutes, whereas FMD remained impaired for at least 90 minutes. Impairment occurred even when marijuana lacked cannabinoids and rolling paper was omitted. Endothelium-independent vasodilation by nitroglycerin administration was not impaired. FMD was not impaired by exposure to chamber air. One minute of exposure to marijuana SHS substantially impairs endothelial function in rats for at least 90 minutes, considerably longer than comparable impairment by tobacco SHS. Impairment of FMD does not require cannabinoids, nicotine, or rolling paper smoke. Our findings in rats suggest that SHS can exert similar adverse cardiovascular effects regardless of whether it is from tobacco or marijuana.

Twitter Demographics

The data shown below were collected from the profiles of 63 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 13%
Canada 2 9%
Switzerland 1 4%
Unknown 17 74%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 43%
Student > Bachelor 4 17%
Other 3 13%
Student > Doctoral Student 3 13%
Professor 1 4%
Other 2 9%
Readers by discipline Count As %
Medicine and Dentistry 9 39%
Agricultural and Biological Sciences 5 22%
Psychology 3 13%
Arts and Humanities 1 4%
Chemical Engineering 1 4%
Other 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 612. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2017.
All research outputs
#4,981
of 8,071,708 outputs
Outputs from Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
#11
of 1,664 outputs
Outputs of similar age
#510
of 257,421 outputs
Outputs of similar age from Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
#2
of 147 outputs
Altmetric has tracked 8,071,708 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 257,421 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.