| Title |
Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure
|
|---|---|
| Published in |
Circulation Research, September 2017
|
| DOI | 10.1161/circresaha.117.310712 |
| Pubmed ID | |
| Authors |
Jorge Bartolucci, Fernando J. Verdugo, Paz L. González, Ricardo E. Larrea, Ema Abarzua, Carlos Goset, Pamela Rojo, Ivan Palma, Ruben Lamich, Pablo A. Pedreros, Gloria Valdivia, Valentina M. Lopez, Carolina Nazzal, Francisca Alcayaga-Miranda, Jimena Cuenca, Matthew J. Brobeck, Amit N. Patel, Fernando E. Figueroa, Maroun Khoury |
| Abstract |
Rationale: Umbilical cord-derived mesenchymal stem cells (UC-MSC) are easily accessible and expanded in vitro, possess distinct properties, and improve myocardial remodeling and function in experimental models of cardiovascular disease. While bone marrow-derived mesenchymal stem cells (BM-MSCs) have been previously assessed for their therapeutic potential in individuals with heart failure and reduced ejection fraction (HFrEF), no clinical trial has evaluated UC-MSCs in these patients. Objective: Evaluate the safety and efficacy of the infusion of UC-MSC in patients with chronic stable HFrEF. Methods and Results: HFrEF patients under optimal medical treatment were randomized to intravenous infusion of allogenic UC-MSCs (Cellistem, Cells for Cells S.A., Santiago, Chile) (1x10(6) cells/Kg) or placebo (n=15 per group). UC-MSCs <em>in vitro</em>, compared to BM-MSCs, displayed a 55-fold increase in the expression of Hepatocyte Growth Factor (HGF), known to be involved in myogenesis, cell migration and immunoregulation. UC-MSC treated patients presented no adverse events related to the cell infusion and none of the patients tested at 0, 15 and 90 days presented alloantibodies to the UC-MSCs (n=7). Only the UC-MSC treated group exhibited significant improvements in left ventricular ejection fraction at 3, 6 and 12 months of follow-up assessed both through transthoracic echocardiography (p=0.0167 versus baseline) and cardiac magnetic resonance imaging (p=0.025 versus baseline). Echocardiographic LVEF change from baseline to month 12 differed significantly between groups (+7.07±6.22% vs +1.85±5.60, p=0.028). In addition, at all follow-up time points, UC-MSCs treated patients displayed improvements of NYHA functional class (p=0.0167 versus baseline) and MLHFQ (p<0.05 versus baseline). At study completion, groups did not differ in mortality, heart failure admissions, arrhythmias or incident malignancy. Conclusions: Intravenous infusion of UC-MSC was safe in this group of patients with stable HFrEF under optimal medical treatment. Improvements in left ventricular function, functional status and quality of life were observed in patients treated with UC-MSCs. Trial registration number: NCT01739777 Registry URL: https://clinicaltrials.gov/ct2/show/NCT01739777. |
X Demographics
The data shown below were collected from the profiles of 35 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 23% |
| United Kingdom | 4 | 11% |
| Lebanon | 2 | 6% |
| Guinea | 1 | 3% |
| Canada | 1 | 3% |
| Georgia | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Argentina | 1 | 3% |
| Colombia | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 12 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 29 | 83% |
| Scientists | 3 | 9% |
| Science communicators (journalists, bloggers, editors) | 3 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 320 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 320 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 39 | 12% |
| Student > Bachelor | 36 | 11% |
| Student > Ph. D. Student | 31 | 10% |
| Student > Master | 26 | 8% |
| Student > Doctoral Student | 20 | 6% |
| Other | 50 | 16% |
| Unknown | 118 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 77 | 24% |
| Biochemistry, Genetics and Molecular Biology | 46 | 14% |
| Agricultural and Biological Sciences | 15 | 5% |
| Nursing and Health Professions | 10 | 3% |
| Engineering | 8 | 3% |
| Other | 35 | 11% |
| Unknown | 129 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 240. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2020.
All research outputs
#156,510
of 25,382,440 outputs
Outputs from Circulation Research
#44
of 7,667 outputs
Outputs of similar age
#3,281
of 328,544 outputs
Outputs of similar age from Circulation Research
#2
of 100 outputs
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